Restriction factors against human CMV

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

CMV: a warrior against leukemia?

In this issue of Blood, Green et al provide additional information supporting that cytomegalovirus (CMV) reduces leukemia relapse after allogeneic stem cell transplantation.

متن کامل

The restriction factors of human immunodeficiency virus.

Cellular proteins called "restriction factors" can serve as powerful blockades to HIV replication, but the virus possesses elaborate strategies to circumvent these barriers. First, we discuss general hallmarks of a restriction factor. Second, we review how the viral Vif protein protects the viral genome from lethal levels of cDNA deamination by promoting APOBEC3 protein degradation; how the vir...

متن کامل

The silent war against CMV in CLL.

In this issue of Blood, Pourgheysari and colleagues demonstrate that there is a highly exaggerated expansion of CMV-specific CD4 T cells in CMV-seropositive compared with CMV-seronegative CLL patients, particularly after chemotherapy.1 Despite this, patient survival is reduced by almost 4 years in the CMV cohort. However, as CMV CLL individuals do not exhibit symptoms of CMV-induced disease, th...

متن کامل

Pretransplantation CMV-specific T cells protect recipients of T-cell-depleted grafts against CMV-related complications.

We have studied cytomegalovirus (CMV) immunity in 17 CMV-positive recipients of T-cell-depleted or T-cell-replete grafts. In recipients of T-cell-replete grafts, the patient's CMV-specific T-cell response was completely ablated. Because primary anti-CMV responses were rare during the first year, immunity depended essentially on the transfer of donor CMV-specific T cells and, therefore, on the C...

متن کامل

Human cellular restriction factors that target HIV-1 replication

Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Future Virology

سال: 2014

ISSN: 1746-0794,1746-0808

DOI: 10.2217/fvl.14.22